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Insulin-like growth factor I [IGF-I]
In humans, plasma IGF-I levels are barely detectable at birth, rise gradually during childhood , peak during mid-puberty until approximately 40 years of age, then decline gradually. In the diagnosis of growth disorders, measurements of IGF-I are a useful indicator of growth hormone (GH) secretion. A normal plasma or serum IGF-I concentration is strong evidence against GH deficiency. A low IGF-I value implies GH deficiency and requires additional testing to determine whether GH secretion is subnormal.
Measurement of IGF-I is also useful in assessing change of nutritional status.
Jun 30, 2010
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